The role of adipose tissue secretion in the creation and pain level in osteoarthritis.
Endocr Regul
; 54(1): 6-13, 2020 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-32597150
ABSTRACT
OBJECTIVES:
With increasing evidence regarding the metabolic basis of osteoarthritis (OA), we studied the relationship between adipose tissue and OA.METHODS:
This study is part of an OA registry in the eastern part of Fars Province, Iran. Overall, 150 patients with OA and 300 sex matched individuals were selected as a control group. They were compared regarding adipokine concentration (leptin, adiponectin, resistin and visfatin), anthropo-metric indices, the Western Ontario and McMaster universities arthritis index score (WOMAC).RESULTS:
All adipokine levels were higher among OA patients (p<0.001). After adjusting for age, sex, and body mass index (BMI), adipokines showed a significant and positive association with OA (B 14.12, B 9.92, B 24.71 and B 12.29 for leptin, adiponectin, visfatin, and resistin, respectively; p<0.001). Except the adiponectin that had a negative relationship with BMI in the OA group (r=-0.570, p<0.001), other adipokines had positive relationships with BMI (r=0.781, p<0.001; r=0.530, p<0.001; r=0.549, p<0.001 for leptin, visfatin, and resistin, respectively). Only leptin and adiponectin levels were correlated with pain (B 0.045, -0.079 and p<0.05).CONCLUSION:
The present study shows that aside to the well-known role of mechanical stress in OA pathogenesis (weight load), leptin, adiponectin, visfatin, and resistin, which represent the adi-pose tissue independent on the weight, may play a chemical role in OA pathogenesis. In addition, leptin and adiponectin may be involved in the pain levels among patients with OA.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
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Sistema de Registros
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Tecido Adiposo
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Citocinas
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Artralgia
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Leptina
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Adiponectina
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Resistina
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Nicotinamida Fosforribosiltransferase
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article