Improvement in HLA-C typing by a new sequence-specific oligonucleotides kit.
HLA
; 96(3): 323-328, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32602630
PCR-sequence-specific oligonucleotide (PCR-SSO) is commonly used for HLA-typing. We recently replaced LabType SSO HD kit for HLA-C typing with the XR kit (OneLambda, Inc.). We used 137 patients' samples representing unique most likely HLA-C allele combinations to compare these kits' performance. The XR kit decreased the number of allele ambiguities with a median of 26.1% (first to third quartiles 20% to 36.2%, range 0% to 96.1%). The XR kit did not resolve all the common, intermediate and well-documented HLA allele ambiguities, which may be important in the clinical setting. The XR kit eliminated 23.6% of null allele ambiguities. In conclusion, the HLA-C XR kit provides a moderate yet valuable improvement of HLA-typing resolution in comparison with the HLA-C HD kit.
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Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
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Antígenos HLA-C
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article