The Lysosome at the Intersection of Cellular Growth and Destruction.
Dev Cell
; 54(2): 226-238, 2020 07 20.
Article
em En
| MEDLINE
| ID: mdl-32610045
ABSTRACT
The lysosome is an essential catabolic organelle that consumes cellular biomass to regenerate basic building blocks that can fuel anabolic reactions. This simple view has evolved more recently to integrate novel functions of the lysosome as a key signaling center, which can steer the metabolic trajectory of cells in response to changes in nutrients, growth factors, and stress. Master protein kinases and transcription factors mediate the growth-promoting and catabolic activities of the lysosome and undergo a complex interplay that enables cellular adaptation to ever-changing metabolic conditions. Understanding how this coordination occurs will shed light on the fundamental logic of how the lysosome functions to control growth in the context of development, tissue homeostasis, and cancer.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Transdução de Sinais
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Ciclo Celular
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Proliferação de Células
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article