Drilling for Oil: Tumor-Surrounding Adipocytes Fueling Cancer.
Trends Cancer
; 6(7): 593-604, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32610069
ABSTRACT
Over the past decade, it has become apparent that metabolic reprogramming is a key event in tumor progression. The tumor microenvironment (TME) is a source of metabolites for tumor cells. Lipid-filled mature adipocytes are frequently found in proximity to invasive human tumors and release free fatty acids (FFAs) through lipolysis. These FFAs are taken up by tumor cells and used to promote tumor progression by mechanisms that include mitochondrial fatty acid oxidation (FAO). This review discusses recent advances in our understanding of this metabolic symbiosis between adipocytes and cancer cells and underlines the differences in this metabolic crosstalk between the various types of cancer and their localization.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Adipócitos
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Ácidos Graxos não Esterificados
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Microambiente Tumoral
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Lipólise
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Neoplasias
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article