Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice.

Qin, Zhaohong; Zhang, Li; Cruz, Shelly A; Stewart, Alexandre F R; Chen, Hsiao-Huei

Qin, Zhaohong; Zhang, Li; Cruz, Shelly A; Stewart, Alexandre F R; Chen, Hsiao-Huei.

Afiliação

Qin Z; Ottawa Hospital Research Institute, Neuroscience, University of Ottawa Brain and Mind Institute, Ottawa, ON, K1H 8M5, Canada.
Zhang L; Ottawa Hospital Research Institute, Neuroscience, University of Ottawa Brain and Mind Institute, Ottawa, ON, K1H 8M5, Canada.
Cruz SA; Ottawa Hospital Research Institute, Neuroscience, University of Ottawa Brain and Mind Institute, Ottawa, ON, K1H 8M5, Canada.
Stewart AFR; University of Ottawa Heart Institute, Ottawa, ON, K1Y 4W7, Canada. astewart@ottawaheart.ca.
Chen HH; Ottawa Hospital Research Institute, Neuroscience, University of Ottawa Brain and Mind Institute, Ottawa, ON, K1H 8M5, Canada. hchen@uottawa.ca.

Neuropsychopharmacology ; 45(11): 1884-1895, 2020 10.

Article em En | MEDLINE | ID: mdl-32610340

Assuntos

Endocanabinoides; Esquizofrenia; Animais; Camundongos; Proteína Tirosina Fosfatase não Receptora Tipo 1; Células Piramidais; Receptor trkB; Receptores de Aminoácido; Reflexo de Sobressalto; Esquizofrenia/genética; Tirosina

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Endocanabinoides Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Endocanabinoides Idioma: En Ano de publicação: 2020 Tipo de documento: Article