Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts.

Zhang, Pei-Pei; Guo, Zhao-Fu; Zhang, Pei-Hua; Liu, Zhi-Pei; Song, Lv; Zhang, Ze-Fu; Jia, Yu-Zhong; Cao, Zhen-Zhen; Ma, Ji-Hua

Zhang, Pei-Pei; Guo, Zhao-Fu; Zhang, Pei-Hua; Liu, Zhi-Pei; Song, Lv; Zhang, Ze-Fu; Jia, Yu-Zhong; Cao, Zhen-Zhen; Ma, Ji-Hua.

Afiliação

Zhang PP; Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China.
Guo ZF; Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China.
Zhang PH; Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China.
Liu ZP; Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China.
Song L; Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China.
Zhang ZF; Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China.
Jia YZ; Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China.
Cao ZZ; Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China.
Ma JH; Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China. mjhua@wust.edu.cn.

Acta Pharmacol Sin ; 42(2): 209-217, 2021 Feb.

Article em En | MEDLINE | ID: mdl-32612277

Assuntos

Fibrilação Atrial/prevenção & controle; Cardiotônicos/farmacologia; Glucosídeos/farmacologia; Miócitos Cardíacos/efeitos dos fármacos; Fenilpropionatos/farmacologia; Potenciais de Ação/efeitos dos fármacos; Animais; Cálcio/metabolismo; Cardiotônicos/administração & dosagem; Venenos de Cnidários/toxicidade; Relação Dose-Resposta a Droga; Eletrocardiografia; Glucosídeos/administração & dosagem; Miócitos Cardíacos/metabolismo; Técnicas de Patch-Clamp; Fenilpropionatos/administração & dosagem; Coelhos; Bloqueadores dos Canais de Sódio/administração & dosagem; Bloqueadores dos Canais de Sódio/farmacologia

Palavras-chave

atrial fibrillation; delayed afterdepolarization; early afterdepolarization; eleutheroside B; late sodium current; patch-clamp techniques

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilpropionatos / Fibrilação Atrial / Cardiotônicos / Miócitos Cardíacos / Glucosídeos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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