Kidney transplantation from small pediatric donors may be feasible to those who developed chronic refractory dialysis hypotension: a single-center experience.

Zheng, Lu; Jia, Hanying; Wang, Rending; Peng, Wenhan; Lv, Junhao; Lei, Wenhua; Liu, Guangjun; Cui, Yu; Chen, Jianghua; Wu, Jianyong

Zheng, Lu; Jia, Hanying; Wang, Rending; Peng, Wenhan; Lv, Junhao; Lei, Wenhua; Liu, Guangjun; Cui, Yu; Chen, Jianghua; Wu, Jianyong.

Afiliação

Zheng L; Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Jia H; Key Laboratory of Nephropathy, Zhejiang Province, Hangzhou, China.
Wang R; Kidney Disease Immunology Laboratory, the Third-Grade Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, China.
Peng W; Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China.
Lv J; Institute of Nephropathy, Zhejiang University, Hangzhou, China.
Lei W; Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Liu G; Key Laboratory of Nephropathy, Zhejiang Province, Hangzhou, China.
Cui Y; Kidney Disease Immunology Laboratory, the Third-Grade Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, China.
Chen J; Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China.
Wu J; Institute of Nephropathy, Zhejiang University, Hangzhou, China.

Ann Transl Med ; 8(11): 683, 2020 Jun.

Article em En | MEDLINE | ID: mdl-32617303

ABSTRACT

ABSTRACT

BACKGROUND:

Chronic refractory dialysis hypotension (CRDH) is a serious issue in dialysis patients waiting for transplants. It leads to fatal clinical outcomes and disqualification from kidney transplantation. Kidney transplantation from pediatric donor to adult patient with lower blood pressure (BP) may be an option. No related study has been reported and we conducted this study to first evaluate the effect of pediatric donor kidney transplantation in CRDH recipients.

METHODS:

Ten single-kidney transplantations from small pediatric donors after cardiac death in our center between August 2016 and April 2018 were described. Half were CRDH recipients (group A) with intradialytic and interdialytic systolic blood pressure (SBP) below 100 mmHg. Each was paired with no-CRDH recipient (control, group B) from the same donor. The operation method of vascular anastomosis and ureterocystoneostomy was the same as that of adult donors. Clinical characteristics, post-operative treatment and outcomes of all recipients were retrieved. Postoperative BP, graft function and size were compared between two groups. The follow-up time was up to April 2019.

RESULTS:

There was no acute rejection (AR), graft loss or death in all recipients after transplantation. Their renal function was recovered despite three transient delayed graft function (DGF). There was no significant difference in serum creatinine (SCr) or graft size (P=0.84, 0.94) after transplantation between two groups. For all CRDH recipients, the postoperative SBP was above 100 mmHg (except one, 90-130 mmHg). The BP one year after transplantation was maintained at 110-125/70-85 mmHg.