Pulsed magnetic field treatment ameliorates the progression of peripheral neuropathy by modulating the neuronal oxidative stress, apoptosis and angiogenesis in a rat model of experimental diabetes.
Arch Physiol Biochem
; 128(6): 1658-1665, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-32633145
ABSTRACT
OBJECTIVE:
The present study aimed to investigate the possible anti-neuropathic effects of daily pulsed magnetic field treatments (PMF) in streptozotocin (60 mg/kg) induced 4 weeks diabetic (type-1) wistar rats (6-8 months). MATERIALS ANDMETHODS:
Body mass, blood glucose and thermal and mechanical sensations were evaluated during the PMF or sham-PMF in diabetic or non-diabetic rats (n = 7/group). After the measurements of motor nerve conduction velocities (MNCV), the levels of several biomarkers for oxidative stress, apoptosis and angiogenesis in spinal cord and sciatic nerve were measured.RESULTS:
PMF for 4 weeks significantly recovered the MCNV (96.9% and 63.9%) and almost fully (100%) restored to the latency and threshold. PMF also significantly suppressed the diabetes induced enhances in biochemical markers of both neuronal tissues.CONCLUSIONS:
Findings suggested that PMF might prevent the development of functional abnormalities in diabetic rats due to its anti-oxidative, anti-apoptotic and anti-angiogenic actions in neuronal tissues.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças do Sistema Nervoso Periférico
/
Diabetes Mellitus Experimental
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article