[Changes in the kallikrein-kinin and complement system in angiography using non-ionic contrast media]. / Veränderungen des Kallikrein-Kinin- und des Komplement-Systems bei Angiographien mit nicht-ionischen Kontrastmitteln.
Klin Wochenschr
; 66(17): 760-3, 1988 Sep 01.
Article
em De
| MEDLINE
| ID: mdl-3263537
ABSTRACT
To examine alterations of the kallikrein-kinin system and of the complement due to the bolus injection of newer non-ionic contrast agents, venous blood samples were taken before and 3 min after angiography. There were no adverse contrast reactions clinically evident. Prekallikrein, kallikrein inhibition, beta-factor XIIa inhibition, C1-esterase inhibitor, C1q, C3, ATIII, HMW-kininogen, fibrinogen and factor XII were determined. Bolus injection of the contrast medium caused an activation of the kallikrein-kinin system (p less than 0.05) with reduction of prekallikrein, kallikrein-inhibition, beta-factor XIIa inhibition and C1-esterase inhibitor. The levels of C1q and C3 were also decreased (p less than 0.05) indicating an activation of the complement. Our results demonstrate, that angiography causes a significant activation of the kallikrein-kinin as well as of the complement system in spite of the use of newer non-ionic contrast agents.
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Base de dados:
MEDLINE
Assunto principal:
Iohexol
/
Iopamidol
/
Angiografia
/
Calicreínas
/
Ativação do Complemento
/
Cininas
Idioma:
De
Ano de publicação:
1988
Tipo de documento:
Article