Statistical Power and the Classical Twin Design.
Twin Res Hum Genet
; 23(2): 87-89, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32638684
ABSTRACT
Dr Nick Martin has made enormous contributions to the field of behavior genetics over the past 50 years. Of his many seminal papers that have had a profound impact, we focus on his early work on the power of twin studies. He was among the first to recognize the importance of sample size calculation before conducting a study to ensure sufficient power to detect the effects of interest. The elegant approach he developed, based on the noncentral chi-squared distribution, has been adopted by subsequent researchers for other genetic study designs, and today remains a standard tool for power calculations in structural equation modeling and other areas of statistical analysis. The present brief article discusses the main aspects of his seminal paper, and how it led to subsequent developments, by him and others, as the field of behavior genetics evolved into the present era.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Gêmeos
/
Estudos em Gêmeos como Assunto
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Genética Comportamental
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article