Altered complexity of resting-state BOLD activity in Alzheimer's disease-related neurodegeneration: a multiscale entropy analysis.
Aging (Albany NY)
; 12(13): 13571-13582, 2020 07 10.
Article
em En
| MEDLINE
| ID: mdl-32649309
ABSTRACT
Brain complexity, which reflects the ability of the brain to adapt to a changing environment, has been found to be significantly changed with age. However, there is less evidence on the alterations of brain complexity in neurodegenerative disorders such as Alzheimer's disease (AD). Here we investigated the altered complexity of resting-state blood oxygen level-dependent signals in AD-related neurodegeneration using multiscale entropy (MSE) analysis. All participants were recruited from the Alzheimer's Disease Neuroimaging Initiative, including healthy controls (HC, n=62), amnestic mild cognitive impairment (aMCI, n =81) patients, and Alzheimer's disease (AD, n=25) patients. Our results showed time scale-dependent MSE differences across the three groups. In scale=1, significantly changed MSE patterns (HC>aMCI>AD) were found in four brain regions, including the hippocampus, middle frontal gyrus, intraparietal lobe, and superior frontal gyrus. In scale=4, reversed MSE patterns (HCPalavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Cognição
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Doença de Alzheimer
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Disfunção Cognitiva
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Amnésia
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article