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The autopsy at the time of SARS-CoV-2: Protocol and lessons.
Carpenito, L; D'Ercole, M; Porta, F; Di Blasi, E; Doi, P; Fagara, G Redolfi; Rey, R; Bulfamante, G.
Afiliação
  • Carpenito L; School of Pathology, University of Milan, Milan, Italy. Electronic address: laura.carpenito@unimi.it.
  • D'Ercole M; School of Pathology, University of Milan, Milan, Italy.
  • Porta F; School of Pathology, University of Milan, Milan, Italy.
  • Di Blasi E; School of Pathology, University of Milan, Milan, Italy.
  • Doi P; Complex Unit of Pathological Anatomy and Medical Genetics, San Paolo Hospital, University of Milan, Milan, Italy.
  • Fagara GR; Complex Unit of Pathological Anatomy and Medical Genetics, San Paolo Hospital, University of Milan, Milan, Italy.
  • Rey R; Complex Unit of Pathological Anatomy and Medical Genetics, San Paolo Hospital, University of Milan, Milan, Italy.
  • Bulfamante G; Complex Unit of Pathological Anatomy and Medical Genetics, San Paolo Hospital, University of Milan, Milan, Italy.
Ann Diagn Pathol ; 48: 151562, 2020 Oct.
Article em En | MEDLINE | ID: mdl-32653819
ABSTRACT
A new viral disease named COVID-19 has recently turned into a pandemic. Compared to a common viral pneumonia it may evolve in an atypical way, causing the rapid death of the patient. For over two centuries, autopsy has been recognized as a fundamental diagnostic technique, particularly for new or little-known diseases. To date, it is often considered obsolete giving the inadequacy to provide samples of a quality appropriate to the sophisticated diagnostic techniques available today. This is probably one of the reasons why during this pandemic autopsies were often requested only in few cases, late and discouraged, if not prohibited, by more than one nation. This is in contrast with our firm conviction to understand the unknown we must look at it directly and with our own eyes. This has led us to implement an autopsy procedure that allows the beginning of the autopsy shortly after death (within 1-2 h) and its rapid execution, also including sampling for ultrastructural and molecular investigations. In our experience, the tissue sample collected for diagnosis and research were of quality similar to biopsy or surgical resections. This procedure was performed ensuring staff and environmental safety. We want to propose our experience, our main qualitative results and a few general considerations, hoping that they can be an incentive to use autopsy with a new procedure adjusted to match the diagnostic challenges of the third millennium.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Manejo de Espécimes / Autopsia / Controle de Infecções / Infecções por Coronavirus Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Manejo de Espécimes / Autopsia / Controle de Infecções / Infecções por Coronavirus Idioma: En Ano de publicação: 2020 Tipo de documento: Article