Relationship between circulating netrin-1 levels, obesity, prediabetes and newly diagnosed type 2 diabetes.
Arch Physiol Biochem
; 128(6): 1533-1538, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-32654547
ABSTRACT
BACKGROUND:
Netrin-1 is presumed to have regenerative, angiogenic and anti-inflammatory properties, thus it could play a substantial role in the development of insulin resistance and T2DM.OBJECTIVE:
The aim of this study was to evaluate the relationship between serum netrin-1 levels and carbohydrate disturbances in patients with obesity.METHODS:
Sample size consisted of 163 patients, divided into four groups obesity without carbohydrate disturbances prediabetes and diabetes and healthy controls Netrin-1 level was determined using ELISA method.RESULTS:
Circulating serum Netrin-1 was significantly lower in patients only with obesity, as well as with those with prediabetes and diabetes in comparison to the control group. Correlation analysis revealed that netrin-1 correlates negatively with BMI, waist, WSR, LDL and positive with sudomotor function. Netrin-1 ≤ 0.17 ng/ml has about 3 fold higher risk for carbohydrate disturbances (OR 3.06, 95% CI 1.48-6.34, p = .003).CONCLUSION:
Netrin-1 is associated with an increased risk for glycaemic disorders in patients with obesity.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estado Pré-Diabético
/
Resistência à Insulina
/
Diabetes Mellitus Tipo 2
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article