Corneal dystrophy in Fischer 344 rats.
Lab Anim Sci
; 38(6): 702-10, 1988 Dec.
Article
em En
| MEDLINE
| ID: mdl-3265461
ABSTRACT
A spontaneous degenerative lesion of the cornea resembling calcific band keratopathy in man has been observed in 10-15% of the F-344 rats (aged 35-300 days) purchased from a private vendor's closed breeding colony. The lesion appears clinically as punctuate to linear superficial corneal opacities located in the interpalpebral fissure of one or both eyes. Occasional roughening, bleb formation, or pitting of the corneal surface resembling superficial ulcers may be observed. The lesion occurs in both sexes. It is rarely associated with inflammation or irritation. Histologically, it consists of mineral deposits along the epithelial basement membrane and Bowman's space, some of which are large enough to disrupt or destroy portions of the basilar epithelium. Energy dispersive X-ray analysis of the deposits proved them to be composed of calcium and phosphorus. Electron microscopic examination revealed a variety of extracellular laminated and crystalline arrays similar to those seen in humans with band keratopathy. The etiology of the lesion is as yet undetermined. A genetic-associated susceptibility due to hypercalcemia may be involved.
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Base de dados:
MEDLINE
Assunto principal:
Ratos Endogâmicos
/
Ratos Endogâmicos F344
/
Doenças dos Roedores
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Distrofias Hereditárias da Córnea
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Córnea
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article