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Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.
Benchekroun, Mohamed; Ermolenko, Ludmila; Tran, Minh Quan; Vagneux, Agathe; Nedev, Hristo; Delehouzé, Claire; Souab, Mohamed; Baratte, Blandine; Josselin, Béatrice; Iorga, Bogdan I; Ruchaud, Sandrine; Bach, Stéphane; Al-Mourabit, Ali.
Afiliação
  • Benchekroun M; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, 91190, France.
  • Ermolenko L; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, 91190, France.
  • Tran MQ; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, 91190, France.
  • Vagneux A; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, 91190, France.
  • Nedev H; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, 91190, France.
  • Delehouzé C; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France; Sorbonne Université, CNRS, UMR 8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France.
  • Souab M; Sorbonne Université, CNRS, FR 2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique de Roscoff, 29680, Roscoff, France.
  • Baratte B; Sorbonne Université, CNRS, FR 2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique de Roscoff, 29680, Roscoff, France.
  • Josselin B; Sorbonne Université, CNRS, FR 2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique de Roscoff, 29680, Roscoff, France.
  • Iorga BI; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, 91190, France.
  • Ruchaud S; Sorbonne Université, CNRS, UMR 8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France.
  • Bach S; Sorbonne Université, CNRS, UMR 8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France; Sorbonne Université, CNRS, FR 2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique de Roscoff, 2968
  • Al-Mourabit A; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, 91190, France. Electronic address: ali.almourabit@cnrs.fr.
Eur J Med Chem ; 201: 112337, 2020 Sep 01.
Article em En | MEDLINE | ID: mdl-32659605
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Inibidores de Proteínas Quinases / Proteína Serina-Treonina Quinases de Interação com Receptores / Necroptose / Imidazóis Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Inibidores de Proteínas Quinases / Proteína Serina-Treonina Quinases de Interação com Receptores / Necroptose / Imidazóis Idioma: En Ano de publicação: 2020 Tipo de documento: Article