Atypical BCL6/GATA3+ Primary Cutaneous Acral CD8-Positive T-Cell Lymphoma: A Diagnostic Challenge.
Am J Dermatopathol
; 43(2): 137-140, 2021 02 01.
Article
em En
| MEDLINE
| ID: mdl-32675470
ABSTRACT
ABSTRACT Primary cutaneous acral CD8-positive T-cell lymphoma consists of slow-growing nodules in acral sites with a histopathology, suggesting high-grade lymphoma despite the indolent clinical course. It has been recently included in WHO-EORTC classification for primary cutaneous lymphomas as a provisional entity. A correct diagnosis of this entity is important because its differential diagnosis include more aggressive cutaneous lymphomas. We present a 53-year-old woman with an indolent solitary nodule on her right leg, which histopathologically showed features of CD8-positive T-cell lymphoma, although with some peculiarities, including epidermotropism, absence of CD68 expression, and positivity for GATA3 and Bcl6 in neoplastic cells. This case could contribute to better define the spectrum of this rare cutaneous lymphoma.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Biomarcadores Tumorais
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Linfócitos do Interstício Tumoral
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Linfoma Cutâneo de Células T
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Linfócitos T CD8-Positivos
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Fator de Transcrição GATA3
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Proteínas Proto-Oncogênicas c-bcl-6
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article