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Pharmacokinetics and Tolerability of the Novel Non-immunosuppressive Fingolimod Derivative, OSU-2S, in Dogs and Comparisons with Data in Mice and Rats.
Xie, Zhiliang; Chen, Min; Goswami, Swagata; Mani, Rajes; Wang, Dasheng; Kulp, Samuel K; Coss, Chris C; Schaaf, Larry J; Cui, Fengyu; Byrd, John C; Jennings, Ryan N; Schober, Karsten K; Freed, Carrie; Lewis, Stephanie; Malbrue, Raphael; Muthusamy, Natarajan; Bennett, Chad; Kisseberth, William C; Phelps, Mitch A.
Afiliação
  • Xie Z; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, 506 Riffe Building, 496 W. 12th Ave., Columbus, Ohio, 43210, USA.
  • Chen M; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, 506 Riffe Building, 496 W. 12th Ave., Columbus, Ohio, 43210, USA.
  • Goswami S; Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
  • Mani R; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
  • Wang D; Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
  • Kulp SK; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
  • Coss CC; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
  • Schaaf LJ; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, 506 Riffe Building, 496 W. 12th Ave., Columbus, Ohio, 43210, USA.
  • Cui F; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, 506 Riffe Building, 496 W. 12th Ave., Columbus, Ohio, 43210, USA.
  • Byrd JC; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
  • Jennings RN; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
  • Schober KK; WuXi AppTec, Shanghai, China.
  • Freed C; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, 506 Riffe Building, 496 W. 12th Ave., Columbus, Ohio, 43210, USA.
  • Lewis S; Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
  • Malbrue R; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
  • Muthusamy N; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
  • Bennett C; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 448 VMAB, 1900 Coffey Rd., Columbus, Ohio, 43210, USA.
  • Kisseberth WC; University Laboratory Animal Resources, The Ohio State University, Columbus, Ohio, USA.
  • Phelps MA; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
AAPS J ; 22(4): 92, 2020 07 16.
Article em En | MEDLINE | ID: mdl-32676788

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Propilenoglicóis / Esfingosina / Cloridrato de Fingolimode / Análise de Dados / Imunossupressores Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Propilenoglicóis / Esfingosina / Cloridrato de Fingolimode / Análise de Dados / Imunossupressores Idioma: En Ano de publicação: 2020 Tipo de documento: Article