Stereoinduction in Metallaphotoredox Catalysis.
Angew Chem Int Ed Engl
; 60(4): 1714-1726, 2021 01 25.
Article
em En
| MEDLINE
| ID: mdl-32677341
ABSTRACT
Metallaphotoredox catalysis has evolved into an enabling platform to construct C(sp3 )-hybridized centers under remarkably mild reaction conditions. The cultivation of abundant radical precursor feedstocks has significantly increased the scope of transition-metal-catalyzed cross-couplings, especially with respect to C(sp2 )-C(sp3 ) linkages. In recent years, considerable effort has been devoted to understanding the origin of stereoinduction in dual catalytic processes. In this context, Ni- and Cu-catalyzed transformations have played a predominant role exploiting this mode of catalysis. Herein, we provide a critical overview on recent progress in enantioselective bond formations enabled by Ni- and Cu-catalyzed manifolds. Furthermore, selected stereochemical control elements within the realm of diastereoselective transformations are discussed.
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MEDLINE
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En
Ano de publicação:
2021
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Article