Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders.

Lin, Guangyao; Liu, Qiaofeng; Dai, Antao; Cai, Xiaoqing; Zhou, Qingtong; Wang, Xi; Chen, Yan; Ye, Chenyu; Li, Jie; Yang, Dehua; Wang, Ming-Wei

Lin, Guangyao; Liu, Qiaofeng; Dai, Antao; Cai, Xiaoqing; Zhou, Qingtong; Wang, Xi; Chen, Yan; Ye, Chenyu; Li, Jie; Yang, Dehua; Wang, Ming-Wei.

Afiliação

Lin G; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.
Liu Q; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Dai A; University of Chinese Academy of Sciences, Beijing 100049, China.
Cai X; School of Pharmacy, Fudan University, Shanghai 201203, China.
Zhou Q; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.
Wang X; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.
Chen Y; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Ye C; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.
Li J; University of Chinese Academy of Sciences, Beijing 100049, China.
Yang D; School of Pharmacy, Fudan University, Shanghai 201203, China.
Wang MW; School of Pharmacy, Fudan University, Shanghai 201203, China.

Biochem J ; 477(13): 2581-2594, 2020 07 17.

Article em En | MEDLINE | ID: mdl-32677665

Assuntos

Doenças Metabólicas/genética; Doenças Metabólicas/metabolismo; Mutação/genética; Receptores de Glucagon/genética; Receptores de Glucagon/metabolismo; Animais; Composição Corporal/genética; Composição Corporal/fisiologia; Células Cultivadas; Feminino; Imunofluorescência; Teste de Tolerância a Glucose; Hepatócitos/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Polimorfismo de Nucleotídeo Único/genética

Palavras-chave

V368M; glucagon receptor; metabolic disorders; mouse model; mutation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Glucagon / Doenças Metabólicas / Mutação Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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