Earlier re-initiation of enteral feeding after necrotizing enterocolitis decreases recurrence or stricture: a systematic review and meta-analysis.
J Perinatol
; 40(11): 1679-1687, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32683411
ABSTRACT
OBJECTIVE:
To assess the effects of earlier vs. later re-initiation of enteral feeds after necrotizing enterocolitis (NEC). STUDYDESIGN:
We reviewed the literature to assess timing of enteral feeding after NEC using fixed effects models.RESULTS:
Three studies met inclusion criteria; no randomized trials. After removal of Bell's Stage I infants, the earlier refeeding group (<5-7 or median 4 days) included 79 infants and later refeeding group (≥5-7 or median 10 days) included 119 infants. Pooled analysis revealed earlier re-initiation reduced the incidence in the composite outcome of recurrent NEC and/or post-NEC stricture (OR = 0.27; 95% Cl = 0.10-0.75; p = 0.012). Individually, NEC recurrence (pooled OR = 0.34; 95% Cl = 0.09-1.29; p = 0.112) or stricture (OR = 0.34; 95% Cl = 0.09-1.26; p = 1.06) did not differ between groups.CONCLUSIONS:
There was no increase in negative outcomes with earlier refeeding after NEC. Earlier initiation of enteral feeds resulted in a significantly lower risk for the combined outcome of recurrent NEC and/or post-NEC stricture.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nutrição Enteral
/
Enterocolite Necrosante
/
Doenças do Recém-Nascido
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article