Post-processing of computed tomography perfusion in patients with acute cerebral ischemia: variability of inter-reader, inter-region of interest, inter-input model, and inter-software.
Eur Radiol
; 30(12): 6561-6569, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32683549
ABSTRACT
OBJECTIVE:
To determine the reproducibility of quantitative computed tomography perfusion (CTP) parameters generated using different post-processing methods and identify the relative impact of subjective factors on the robustness of CTP parameters in acute ischemic stroke (AIS). MATERIALS ANDMETHODS:
A total of 80 CTP datasets from patients with AIS or transient ischemic attack (TIA) were retrospectively post-processed by two observers using different regions of interest (ROI) types, input models, and software. The CTP parameters were derived for 10 parenchymal ROIs. The intra-class correlation coefficients (ICCs) were used to assess the reproducibility of the CTP parameters for various post-processing methods. The Spearman correlation test was used to detect potential relationships between software and input models.RESULTS:
The ICCs with 95% confidence intervals (CIs) were 0.94 (0.93-0.96), 0.94 (0.92-0.96), 0.82 (0.79-0.86), and 0.87 (0.85-0.90) for inter-reader agreement by using elliptic ROI, irregular ROI, single-input model, and dual-input model, respectively. The ICCs with 95% CI were 0.98 (0.98-0.98), 0.46 (0.43-0.50), and 0.25 (0.20-0.30) for inter-ROI type, inter-input model, and inter-software agreement, respectively.CONCLUSIONS:
Although the CTP parameters were stable when measured using different readers with different ROI types, they varied for different input models and software. The standardization of CTP post-processing is essential to reduce variability of CTP values. KEY POINTS ⢠The CTP parameters derived by different readers with different ROI types have agreements that range from good to excellent. ⢠The CTP parameters derived from different input models and software programs have poor agreement but significant correlations.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Tomografia Computadorizada por Raios X
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Isquemia Encefálica
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Circulação Cerebrovascular
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Imagem de Perfusão
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article