The origins and genomic diversity of American Civil War Era smallpox vaccine strains.
Genome Biol
; 21(1): 175, 2020 07 20.
Article
em En
| MEDLINE
| ID: mdl-32684155
ABSTRACT
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination. Prior to the twentieth century, the method, source and origin of smallpox vaccinations remained unstandardised and opaque. We reconstruct and analyse viral vaccine genomes associated with smallpox vaccination from historical artefacts. Significantly, we recover viral molecules through non-destructive sampling of historical materials lacking signs of biological residues. We use the authenticated ancient genomes to reveal the evolutionary relationships of smallpox vaccination viruses within the poxviruses as a whole.
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Base de dados:
MEDLINE
Assunto principal:
Vaccinia virus
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Vacina Antivariólica
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Genoma Viral
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article