Effects of ABCB1, UGT1A1, and UGT1A9 Genetic Polymorphisms on the Pharmacokinetics of Sitafloxacin Granules in Healthy Subjects.

Sun, Lu-Ning; Sun, Guo-Xian; Yang, Yu-Qing; Shen, Ye; Huang, Feng-Ru; Xie, Li-Jun; Cheng, Juan; Zhang, Hong-Wen; Zhang, Xue-Hui; Liu, Yun; Wang, Yong-Qing

Sun, Lu-Ning; Sun, Guo-Xian; Yang, Yu-Qing; Shen, Ye; Huang, Feng-Ru; Xie, Li-Jun; Cheng, Juan; Zhang, Hong-Wen; Zhang, Xue-Hui; Liu, Yun; Wang, Yong-Qing.

Afiliação

Sun LN; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Sun GX; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yang YQ; Department of Pharmacy, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Shen Y; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Huang FR; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xie LJ; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Cheng J; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhang HW; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhang XH; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Liu Y; Department of Pharmacy, Jiangsu Shengze Hospital, Suzhou, China.
Wang YQ; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Clin Pharmacol Drug Dev ; 10(1): 57-67, 2021 01.

Article em En | MEDLINE | ID: mdl-32687695

Assuntos

Antibacterianos/farmacocinética; Fluoroquinolonas/farmacocinética; Glucuronosiltransferase/genética; UDP-Glucuronosiltransferase 1A/genética; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética; Administração Oral; Adolescente; Adulto; Antibacterianos/administração & dosagem; Antibacterianos/efeitos adversos; Estudos Cross-Over; Formas de Dosagem; Jejum/metabolismo; Feminino; Fluoroquinolonas/administração & dosagem; Fluoroquinolonas/efeitos adversos; Interações Alimento-Droga; Genótipo; Voluntários Saudáveis; Humanos; Masculino; Polimorfismo de Nucleotídeo Único; Adulto Jovem

Palavras-chave

ABCB1; UGT1A1; UGT1A9; gene polymorphism; pharmacokinetics; safety; sitafloxacin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glucuronosiltransferase / Fluoroquinolonas / UDP-Glucuronosiltransferase 1A / Antibacterianos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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