Your browser doesn't support javascript.
loading
Risk of late health effects after soft-tissue sarcomas in childhood - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme.
Norsker, Filippa Nyboe; Boschini, Cristina; Rechnitzer, Catherine; Holmqvist, Anna Sällfors; Tryggvadottir, Laufey; Madanat-Harjuoja, Laura-Maria; Schrøder, Henrik; Scheike, Thomas H; Hasle, Henrik; Winther, Jeanette Falck; Andersen, Klaus Kaae.
Afiliação
  • Norsker FN; Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Boschini C; Unit of Statistics and Pharmaco-epidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Rechnitzer C; Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
  • Holmqvist AS; Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
  • Tryggvadottir L; Division of Paediatric Oncology and Hematology, Skane University Hospital, Lund, Sweden.
  • Madanat-Harjuoja LM; Department of Clinical Sciences, Lund University, Lund, Sweden.
  • Schrøder H; The Icelandic Cancer Registry, Reykjavik, Iceland.
  • Scheike TH; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  • Hasle H; The Finnish Cancer Registry, Helsinki, Finland.
  • Winther JF; Dana Farber Cancer Institute, Harvard University, Boston, MA, USA.
  • Andersen KK; Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
Acta Oncol ; 59(10): 1246-1256, 2020 Oct.
Article em En | MEDLINE | ID: mdl-32692292
ABSTRACT

BACKGROUND:

In the 1960s only 1/3 of children with soft-tissue sarcomas survived, however with improved treatments survival today has reached 70%. Given the previous poor survival and the rarity of soft-tissue sarcomas, the risk of somatic late effects in a large cohort of Nordic soft-tissue sarcoma survivors has not yet been assessed.

METHODS:

In this population-based cohort study we identified 985 five-year soft-tissue sarcoma survivors in Nordic nationwide cancer registries and late effects in national hospital registries covering the period 1964-2012. Information on tumour site and radiotherapy was available for Danish and Finnish survivors (N = 531). Using disease-specific rates of first-time hospital contacts for somatic diseases in survivors and in 4,830 matched comparisons we calculated relative rates (RR) and rate differences (RD).

RESULTS:

Survivors had a RR of 1.5 (95% CI 1.4-1.7) and an absolute RD of 23.5 (17.7-29.2) for a first hospital contact per 1,000 person-years. The highest risks in both relative and absolute terms were of endocrine disorders (RR = 2.5; RD = 7.6), and diseases of the nervous system (RR = 1.9; RD = 6.6), digestive organs (RR = 1.7; RD = 5.4) and urinary system (RR = 1.7; RD = 5.6). By tumour site, excess risk was lower after extremity tumours. Irradiated survivors had a 2.6 (1.2-5.9) times higher risk than non-irradiated.

CONCLUSIONS:

Soft-tissue sarcoma survivors have an increased risk of somatic late effects in 5 out of 10 main diagnostic groups of diseases, and the risk remains increased up to 40 years after cancer diagnosis. Risks were slightly lower for those treated for tumours in the extremities, and radiotherapy increased the risk by more than two-fold.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcoma / Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcoma / Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article