Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development.
Elife
; 92020 07 21.
Article
em En
| MEDLINE
| ID: mdl-32692310
ABSTRACT
Early life adversity (ELA) is associated with increased risk for stress-related disorders later in life. The link between ELA and risk for psychopathology is well established but the developmental mechanisms remain unclear. Using a mouse model of resource insecurity, limited bedding (LB), we tested the effects of LB on the development of fear learning and neuronal structures involved in emotional regulation, the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA). LB delayed the ability of peri-weanling (21 days old) mice to express, but not form, an auditory conditioned fear memory. LB accelerated the developmental emergence of parvalbumin (PV)-positive cells in the BLA and increased anatomical connections between PL and BLA. Fear expression in LB mice was rescued through optogenetic inactivation of PV-positive cells in the BLA. The current results provide a model of transiently blunted emotional reactivity in early development, with latent fear-associated memories emerging later in adolescence.
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Base de dados:
MEDLINE
Assunto principal:
Proliferação de Células
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Extinção Psicológica
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Medo
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Experiências Adversas da Infância
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Tonsila do Cerebelo
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Memória
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Vias Neurais
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article