Efficacy of Pulmonary Artery Pulsatility Index as a Measure of Right Ventricular Dysfunction in Stable Phase of Dilated Cardiomyopathy.
Circ J
; 84(9): 1536-1543, 2020 08 25.
Article
em En
| MEDLINE
| ID: mdl-32713875
ABSTRACT
BACKGROUND:
Right ventricular dysfunction (RVD) in the setting of left ventricular (LV) myocardial damage is a major cause of morbidity and mortality, and the pulmonary artery pulsatility index (PAPi) is a novel hemodynamic index shown to predict RVD in advanced heart failure. However, it is unknown whether PAPi can predict the long-term prognosis of dilated cardiomyopathy (DCM) even in the mild to moderate phase. This study aimed to assess the ability of PAPi to stratify DCM patients without severe symptoms.MethodsâandâResults:
Between April 2000 and March 2018, a total of 162 DCM patients with stable symptoms were evaluated, including PAPi, and followed up for a median of 4.91 years. The mean age was 50.9±12.6 years and the mean LV ejection fraction (EF) was 30.5±8.3%. When divided into 2 groups based on median value of PAPi (low, L-PAPi [<3.06] and high, H-PAPi [≥3.06]), even though there were no differences in B-type natriuretic peptide or pulmonary vascular resistance, the probability of cardiac event survival was significantly higher in the L-PAP than in the H-PAP group by Kaplan-Meier analysis (P=0.018). Furthermore, Cox's proportional hazard regression analysis revealed that PAPi was an independent predictor of cardiac events (hazard ratio 0.782, P=0.010).CONCLUSIONS:
Even in patients identified with DCM in the mild to moderate phase, PAPi may help stratify DCM and predict cardiac events.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Artéria Pulmonar
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Fluxo Pulsátil
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Cardiomiopatia Dilatada
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Função Ventricular Direita
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Disfunção Ventricular Direita
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article