A quantitative modelling approach to zebrafish pigment pattern formation.
Elife
; 92020 07 27.
Article
em En
| MEDLINE
| ID: mdl-32716296
Pattern formation is a key aspect of development. Adult zebrafish exhibit a striking striped pattern generated through the self-organisation of three different chromatophores. Numerous investigations have revealed a multitude of individual cell-cell interactions important for this self-organisation, but it has remained unclear whether these known biological rules were sufficient to explain pattern formation. To test this, we present an individual-based mathematical model incorporating all the important cell-types and known interactions. The model qualitatively and quantitatively reproduces wild type and mutant pigment pattern development. We use it to resolve a number of outstanding biological uncertainties, including the roles of domain growth and the initial iridophore stripe, and to generate hypotheses about the functions of leopard. We conclude that our rule-set is sufficient to recapitulate wild-type and mutant patterns. Our work now leads the way for further in silico exploration of the developmental and evolutionary implications of this pigment patterning system.
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Base de dados:
MEDLINE
Assunto principal:
Peixe-Zebra
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Pigmentação
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Cromatóforos
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Padronização Corporal
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article