CT lung lesions as predictors of early death or ICU admission in COVID-19 patients.
Clin Microbiol Infect
; 26(10): 1417.e5-1417.e8, 2020 Oct.
Article
em En
| MEDLINE
| ID: mdl-32717417
ABSTRACT
OBJECTIVE:
The main objective of this study was to investigate the prognostic value of early systematic chest computed tomography (CT) with quantification of lung lesions in coronavirus disease 2019 (COVID-19) patients.METHODS:
We studied 572 patients diagnosed with COVID-19 (confirmed using polymerase chain reaction) for whom a chest CT was performed at hospital admission. Visual quantification was used to classify patients as per the percentage of lung parenchyma affected by COVID-19 lesions normal CT, 0-10%, 11-25%, 26-50%, 51-75% and >75%. The primary endpoint was severe disease, defined by death or admission to the intensive care unit in the 7 days following first admission.RESULTS:
The mean patient age was 66.0 ± 16.0 years, and 343/572 (60.0%) were men. The primary endpoint occurred in 206/572 patients (36.0%). The extent of lesions on initial CT was independently associated with prognosis (odds ratio = 2.35, 95% confidence interval 1.24-4.46; p < 0.01). Most patients with lung involvement >50% (66/95, 69.5%) developed severe disease compared to patients with lung involvement of 26-50% (70/171, 40.9%) and ≤25% (70/306, 22.9%) (p < 0.01 and p < 0.01, respectively). None of the patients with normal CT (0/14) had severe disease.CONCLUSION:
Chest CT findings at admission are associated with outcome in COVID-19 patients.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
/
Infecções por Coronavirus
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Betacoronavirus
/
Pulmão
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article