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Bioactive Metabolites from the Deep-Sea-Derived Fungus Diaporthe longicolla FS429.
Liu, Zhaoming; Chen, Yuchan; Li, Saini; Wang, Qinglin; Hu, Caiyun; Liu, Hongxin; Zhang, Weimin.
Afiliação
  • Liu Z; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu Di
  • Chen Y; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu Di
  • Li S; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu Di
  • Wang Q; School of Life Sciences and Biomedical Center, Sun Yat-Sen University, Guangzhou 510275, China.
  • Hu C; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu Di
  • Liu H; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu Di
  • Zhang W; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu Di
Mar Drugs ; 18(8)2020 Jul 23.
Article em En | MEDLINE | ID: mdl-32717916
ABSTRACT
The chemical investigation of a methanol extract of the deep-sea-derived fungus Diaporthe longicolla FS429 led to the isolation of two novel diterpenoids longidiacids A and B (1 and 2), two new polyketides (3 and 4), two new cytochalasin analogues longichalasins A and B (6 and 8) and three known analogues 5, 7, 9. Their structures were elucidated through comprehensive spectroscopic analysis, while the absolute configurations were established by the comparison of the experimental and quantum chemical calculated ECD spectra. The structure of compound 7 was confirmed through X-ray diffraction for the first time. In the bioassays compound 8 exhibited antiproliferative effects against SF-268, with an IC50 value of 16.44 µM. Moreover, compounds 1 and 8 were detected to inhibit 35.4% and 53.5% of enzyme activity of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) at a concentration of 50 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ascomicetos / Proteínas de Bactérias / Proteínas Tirosina Fosfatases / Proliferação de Células / Inibidores Enzimáticos / Mycobacterium tuberculosis / Antineoplásicos / Antituberculosos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ascomicetos / Proteínas de Bactérias / Proteínas Tirosina Fosfatases / Proliferação de Células / Inibidores Enzimáticos / Mycobacterium tuberculosis / Antineoplásicos / Antituberculosos Idioma: En Ano de publicação: 2020 Tipo de documento: Article