Importance of the Immunodominant CD8<sup>+</sup> T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection.

Gibbins, Matthew P; Müller, Katja; Glover, Maya; Liu, Jasmine; Putrianti, Elyzana D; Bauza, Karolis; Reyes-Sandoval, Arturo; Matuschewski, Kai; Silvie, Olivier; Hafalla, Julius Clemence R

Importance of the Immunodominant CD8⁺ T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection.

Gibbins, Matthew P; Müller, Katja; Glover, Maya; Liu, Jasmine; Putrianti, Elyzana D; Bauza, Karolis; Reyes-Sandoval, Arturo; Matuschewski, Kai; Silvie, Olivier; Hafalla, Julius Clemence R.

Afiliação

Gibbins MP; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Müller K; Parasitology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.
Glover M; Department of Molecular Parasitology, Institute of Biology, Humboldt University, Berlin, Germany.
Liu J; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Putrianti ED; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Bauza K; Parasitology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.
Reyes-Sandoval A; Department of Molecular Parasitology, Institute of Biology, Humboldt University, Berlin, Germany.
Matuschewski K; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Silvie O; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Hafalla JCR; Parasitology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.

Infect Immun ; 88(10)2020 09 18.

Article em En | MEDLINE | ID: mdl-32719159

Assuntos

Linfócitos T CD8-Positivos/imunologia; Epitopos de Linfócito T/imunologia; Vacinas Antimaláricas/imunologia; Malária/prevenção & controle; Plasmodium berghei/imunologia; Proteínas de Protozoários/imunologia; Animais; Anticorpos Antiprotozoários/sangue; Anticorpos Antiprotozoários/imunologia; Apresentação de Antígeno; Antígenos de Protozoários/genética; Antígenos de Protozoários/imunologia; Modelos Animais de Doenças; Epitopos de Linfócito T/química; Imunização; Malária/imunologia; Malária/parasitologia; Vacinas Antimaláricas/administração & dosagem; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Fragmentos de Peptídeos; Proteínas de Protozoários/química; Especificidade da Espécie; Esporozoítos/imunologia

Palavras-chave

CD8+ T cells; Plasmodium; apicomplexan parasites; circumsporozoite; malaria; murine models; parasite; protection; vaccine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium berghei / Proteínas de Protozoários / Vacinas Antimaláricas / Linfócitos T CD8-Positivos / Epitopos de Linfócito T / Malária Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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