A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring.

Singh, Amit Kumar; Kundu, Moumita; Roy, Samrat; Roy, Biswajit; Shah, Sk Sheriff; Nair, Asha V; Pal, Bipul; Mondal, Mahitosh; Singh, N D Pradeep

Singh, Amit Kumar; Kundu, Moumita; Roy, Samrat; Roy, Biswajit; Shah, Sk Sheriff; Nair, Asha V; Pal, Bipul; Mondal, Mahitosh; Singh, N D Pradeep.

Afiliação

Singh AK; Department of Chemistry, Indian Institute of Technology Kharagpur, 721302 Kharagpur, West Bengal, India. ndpradeep@chem.iitkgp.ac.in.

Chem Commun (Camb) ; 56(69): 9986-9989, 2020 Sep 07.

Article em En | MEDLINE | ID: mdl-32720950

ABSTRACT

ABSTRACT

We report a two-photon responsive drug delivery system (DDS), namely, p-hydroxyphenacyl-naphthalene-chlorambucil (pHP-Naph-Cbl), having a two-photon absorption (TPA) cross-section of ≥20 GM in the phototherapeutic window (700 nm). Our DDS exhibited both AIE and ESIPT phenomena, which were utilized for the real-time monitoring of anti-cancer drug release.

Assuntos

Antineoplásicos Alquilantes/química; Clorambucila/química; Portadores de Fármacos/química; Naftalenos/química; Antineoplásicos Alquilantes/metabolismo; Antineoplásicos Alquilantes/farmacologia; Sobrevivência Celular/efeitos dos fármacos; Clorambucila/metabolismo; Clorambucila/farmacologia; Liberação Controlada de Fármacos; Humanos; Luz; Células MCF-7; Microscopia Confocal; Fótons

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Clorambucila / Antineoplásicos Alquilantes / Naftalenos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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