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Multidrug Resistant Tuberculosis With Simultaneously Acquired Drug Resistance to Bedaquiline and Delamanid.
Yoshiyama, Takashi; Takaki, Akiko; Aono, Akio; Mitarai, Satoshi; Okumura, Masao; Ohta, Ken; Kato, Seiya.
Afiliação
  • Yoshiyama T; Research Institute of Tuberculosis, Tokyo, Japan.
  • Takaki A; Respiratory Diseases Center, Fukujuji Hospital, Tokyo, Japan.
  • Aono A; Department of Mycobacterium Reference and Research, Research institute of tuberculosis, Tokyo, Japan.
  • Mitarai S; Department of Mycobacterium Reference and Research, Research institute of tuberculosis, Tokyo, Japan.
  • Okumura M; Department of Mycobacterium Reference and Research, Research institute of tuberculosis, Tokyo, Japan.
  • Ohta K; Respiratory Diseases Center, Fukujuji Hospital, Tokyo, Japan.
  • Kato S; Fukujuji Hospital, Tokyo, Japan.
Clin Infect Dis ; 73(12): 2329-2331, 2021 12 16.
Article em En | MEDLINE | ID: mdl-32730621
ABSTRACT
This study is the first to report a clinical case of simultaneously acquired resistance to bedaquiline (BDQ) and delamanid (DLM). Whole genome sequencing revealed 2 nucleotide insertions (Rv0678 and fbiC) in the Mycobacterium tuberculosis isolate. The minimum inhibitory concentrations for BDQ and DLM were 0.25 µg/mL and >2.0 µg/mL, respectively.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Mycobacterium tuberculosis / Nitroimidazóis Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Mycobacterium tuberculosis / Nitroimidazóis Idioma: En Ano de publicação: 2021 Tipo de documento: Article