Association of Serum Biomarker Levels and BDNF Gene Polymorphism with Response to Selective Serotonin Reuptake Inhibitors in Indian Patients with Major Depressive Disorder.
Neuropsychobiology
; 80(3): 201-213, 2021.
Article
em En
| MEDLINE
| ID: mdl-32731218
ABSTRACT
INTRODUCTION:
Depression is a major public health problem. Response to selective serotonin reuptake inhibitor (SSRI) treatment varies considerably between patients. In the context of polygenic diseases like depression, measurement of a panel of biomarkers involved in the pathophysiology of depression might help predict outcome to treatment with SSRIs.OBJECTIVE:
The objective was to establish the relationship between serum biomarker levels and the brain-derived neurotrophic factor (BDNF) val66met polymorphism and response to SSRIs in patients with major depressive disorder.METHODS:
50 patients with moderate to severe depression were recruited from the Department of Psychiatry, Sri Ra-machandra Institute of Higher Education and Research. Blood samples were collected, and Hamilton Depression Rating Scale scoring was done at baseline and after 8 weeks of treatment with SSRIs. Baseline and post-treatment levels of high-sensitivity C-reactive protein (hsCRP), BDNF and neuregulin 1ß1 (NRG1ß1) were analysed using commercially available ELISA kits. Genotyping of the BDNF Val66Met polymorphism was performed using a PCR-RFLP method.RESULTS:
Following treatment, there was a significant decrease in the mean hsCRP and NRG1ß1 levels and a significant increase in the mean BDNF level. Responders had significantly lower baseline hsCRP and higher baseline BDNF levels when compared to non-responders. Response rates were significantly higher in the Val/Val group when compared to the Val/Met group.CONCLUSIONS:
Baseline serum levels of hsCRP and BDNF predicted response to SSRIs in major depressive disorder, and Val/Val patients responded better when compared to patients carrying the Met allele.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Inibidores Seletivos de Recaptação de Serotonina
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Fator Neurotrófico Derivado do Encéfalo
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Transtorno Depressivo Maior
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article