Radioprotective effect of chloropyllin, protoporphyrin-IX and bilirubin compared with amifostine® in Drosophila melanogaster.
Environ Toxicol Pharmacol
; 80: 103464, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32750419
ABSTRACT
The identification of substances that prevent or minimize the detrimental effects of ionizing radiation is an essential undertaking. The aim of this paper was to evaluate and compare the radioprotective potential of chlorophyllin, protoporphyrin and bilirubin, with amifostine®, an US Food & Drug Administration approved radioprotector Using the somatic mutation and recombination assay in the Drosophila melanogaster wing, it was found that pretreatment (1-9â¯h) with any of the porphyrins or amifostine® alone, did not affect the larva-adult viability or the basal frequency of mutation. However, they were associated with significant reductions in frequency of somatic mutation and recombination compared with the gamma-irradiated (20â¯Gy) control as follows bilirubin (69.3 %)> chlorophyllin (40.0 %)> protoporphyrin (39.0 %)> amifostine® (19.7 %). Bilirubin also caused a 16 % increase in larva-adult viability with 3â¯h of pretreatment respect to percentage induced in 20â¯Gy control group. Whilst amifostine® was associated with lower genetic damage after pre-treatment of 1 and 3â¯h, this did not attain significance. These findings suggest that the tested porphyrins may have some potential as radioprotectant agents.
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Base de dados:
MEDLINE
Assunto principal:
Protoporfirinas
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Protetores contra Radiação
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Bilirrubina
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Clorofilídeos
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Amifostina
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Drosophila melanogaster
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article