Inter-individual differences in immune profiles of outbred rats screened for an emotional reactivity phenotype.
J Neuroimmunol
; 347: 577349, 2020 10 15.
Article
em En
| MEDLINE
| ID: mdl-32750564
ABSTRACT
Inter-individual differences in emotional reactivity predict susceptibility versus resilience to mood pathology. Using experimentally-naïve outbred rats that vary in locomotor reactivity to the mild stress of an inescapable novel environment [i.e., top and bottom 1/3rd of the population identified as high responders (HR) and low responders (LR) respectively], we determined baseline variations in immune functions. Innate and adaptive immune responses vary basally in LRHR rats, namely a shift towards TH1 in LRs and TH2 in HRs was observed. These inter-individual variations in immune profiles in LRHRs could have significant implications in mood alterations and immune reactivity to microbes and cancer.
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Base de dados:
MEDLINE
Assunto principal:
Fenótipo
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Transtornos do Humor
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Imunidade Adaptativa
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Imunidade Inata
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Individualidade
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article