Overcoming Multiple Absorption Barrier for Insulin Oral Delivery Using Multifunctional Nanoparticles Based on Chitosan Derivatives and Hyaluronic Acid.

Chen, Zuxian; Han, Shangcong; Yang, Xiaotang; Xu, Lisa; Qi, Hong; Hao, Guizhou; Cao, Jie; Liang, Yan; Ma, Qingming; Zhang, Guimin; Sun, Yong

Chen, Zuxian; Han, Shangcong; Yang, Xiaotang; Xu, Lisa; Qi, Hong; Hao, Guizhou; Cao, Jie; Liang, Yan; Ma, Qingming; Zhang, Guimin; Sun, Yong.

Afiliação

Chen Z; Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China.
Han S; Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China.
Yang X; Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China.
Xu L; Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China.
Qi H; Department of General Surgery, Qingdao Municipal Hospital, Qingdao 266071, People's Republic of China.
Hao G; Department of Scientific Research, Lunan Pharmaceutical Corporation, Linyi 276001, People's Republic of China.
Cao J; Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China.
Liang Y; Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China.
Ma Q; Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China.
Zhang G; Department of Scientific Research, Lunan Pharmaceutical Corporation, Linyi 276001, People's Republic of China.
Sun Y; Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China.

Int J Nanomedicine ; 15: 4877-4898, 2020.

Article em En | MEDLINE | ID: mdl-32753869

Assuntos

Quitosana/química; Ácido Hialurônico/química; Insulina/administração & dosagem; Nanopartículas Multifuncionais/química; Nanopartículas/química; Administração Oral; Animais; Transporte Biológico/efeitos dos fármacos; Células CACO-2; Morte Celular/efeitos dos fármacos; Quitosana/síntese química; Diabetes Mellitus Experimental/tratamento farmacológico; Impedância Elétrica; Endocitose/efeitos dos fármacos; Guanidinas/síntese química; Guanidinas/química; Humanos; Ácido Hialurônico/síntese química; Hipoglicemiantes/administração & dosagem; Hipoglicemiantes/farmacologia; Insulina/uso terapêutico; Absorção Intestinal/efeitos dos fármacos; Masculino; Muco/metabolismo; Nanopartículas/ultraestrutura; Ratos; Solubilidade; Suínos

Palavras-chave

caveolae-mediated transport; insulin; oral drug delivery; paracellular pathway; transepithelial transport

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quitosana / Nanopartículas / Nanopartículas Multifuncionais / Ácido Hialurônico / Insulina Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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