Differential MHC-II expression and phagocytic functions of embryo-derived cardiac macrophages in the course of myocardial infarction in mice.
Eur J Immunol
; 51(1): 250-252, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-32761616
ABSTRACT
In mouse myocardial infarction, we combined lineage tracing of cardiac macrophages, mapping their ontogeny, with an analysis of their phenotype and phagocytic functions. While embryo-derived macrophages were most abundant in homeostasis, bone marrow-derived MHC-IIlo macrophages increased in both numbers and phagocytic capacity to clear necrotic cardiomyocytes early after ischemia/perfusion injury.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe II
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Macrófagos
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Infarto do Miocárdio
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Miocárdio
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article