Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells.

Schild, Achille; Bhardwaj, Rajesh; Wenger, Nicolas; Tscherrig, Dominic; Kandasamy, Palanivel; Dernic, Jan; Baur, Roland; Peinelt, Christine; Hediger, Matthias A; Lochner, Martin

Schild, Achille; Bhardwaj, Rajesh; Wenger, Nicolas; Tscherrig, Dominic; Kandasamy, Palanivel; Dernic, Jan; Baur, Roland; Peinelt, Christine; Hediger, Matthias A; Lochner, Martin.

Afiliação

Schild A; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Bhardwaj R; Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Wenger N; Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Tscherrig D; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Kandasamy P; Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Dernic J; Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Baur R; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Peinelt C; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.
Hediger MA; Department of BioMedical Research, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Lochner M; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.

Int J Mol Sci ; 21(16)2020 Aug 05.

Article em En | MEDLINE | ID: mdl-32764353

Assuntos

Compostos de Boro/farmacologia; Neoplasias da Mama/tratamento farmacológico; Proteínas de Neoplasias/genética; Proteína ORAI1/genética; Molécula 1 de Interação Estromal/genética; Moléculas de Interação Estromal/genética; Animais; Compostos de Boro/síntese química; Neoplasias da Mama/genética; Neoplasias da Mama/patologia; Cálcio/metabolismo; Sinalização do Cálcio/efeitos dos fármacos; Retículo Endoplasmático/efeitos dos fármacos; Retículo Endoplasmático/genética; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Complexos Multiproteicos/antagonistas & inibidores; Complexos Multiproteicos/genética; Proteínas de Neoplasias/antagonistas & inibidores; Proteína ORAI1/química; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/genética; Molécula 1 de Interação Estromal/antagonistas & inibidores; Moléculas de Interação Estromal/antagonistas & inibidores

Palavras-chave

2-APB; breast cancer cells; calcium imaging assay; inhibitors; patch-clamp electrophysiology; store-operated calcium entry; structureactivity relationship; synthetic chemistry

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Compostos de Boro / Moléculas de Interação Estromal / Molécula 1 de Interação Estromal / Proteína ORAI1 / Proteínas de Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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