Your browser doesn't support javascript.
loading
Expanding Our Understanding of Ovarian Cancer Risk: The Role of Incomplete Pregnancies.
Lee, Alice W; Rosenzweig, Stacey; Wiensch, Ashley; Ramus, Susan J; Menon, Usha; Gentry-Maharaj, Aleksandra; Ziogas, Argyrios; Anton-Culver, Hoda; Whittemore, Alice S; Sieh, Weiva; Rothstein, Joseph H; McGuire, Valerie; Wentzensen, Nicolas; Bandera, Elisa V; Qin, Bo; Terry, Kathryn L; Cramer, Daniel W; Titus, Linda; Schildkraut, Joellen M; Berchuck, Andrew; Goode, Ellen L; Kjaer, Susanne K; Jensen, Allan; Jordan, Susan J; Ness, Roberta B; Modugno, Francesmary; Moysich, Kirsten; Thompson, Pamela J; Goodman, Marc T; Carney, Michael E; Chang-Claude, Jenny; Rossing, Mary Anne; Harris, Holly R; Doherty, Jennifer Anne; Risch, Harvey A; Khoja, Lilah; Alimujiang, Aliya; Phung, Minh Tung; Brieger, Katharine; Mukherjee, Bhramar; Pharoah, Paul D P; Wu, Anna H; Pike, Malcolm C; Webb, Penelope M; Pearce, Celeste Leigh.
Afiliação
  • Lee AW; Department of Public Health, California State University, Fullerton, Fullerton, CA, USA.
  • Rosenzweig S; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Wiensch A; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Ramus SJ; School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, New South Wales, Australia.
  • Menon U; Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, New South Wales, Australia.
  • Gentry-Maharaj A; Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, New South Wales, Australia.
  • Ziogas A; MRC Clinical Trials Unit, Institute of Clinical Trials & Methodology, University College London, London, UK.
  • Anton-Culver H; MRC Clinical Trials Unit, Institute of Clinical Trials & Methodology, University College London, London, UK.
  • Whittemore AS; Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.
  • Sieh W; Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA.
  • Rothstein JH; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.
  • McGuire V; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.
  • Wentzensen N; Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.
  • Bandera EV; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
  • Qin B; Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • Terry KL; Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • Cramer DW; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
  • Titus L; Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Schildkraut JM; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
  • Berchuck A; Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Goode EL; Departments of Epidemiology and of Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Kjaer SK; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
  • Jensen A; Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
  • Jordan SJ; Division of Epidemiology, Department of Health Science Research, Mayo Clinic, Rochester, MN, USA.
  • Ness RB; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Modugno F; Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Moysich K; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Thompson PJ; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Goodman MT; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Carney ME; Womens Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, PA, USA.
  • Chang-Claude J; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Rossing MA; Division of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
  • Harris HR; Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Doherty JA; Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Risch HA; Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Khoja L; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
  • Alimujiang A; Cancer Epidemiology Group, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Phung MT; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Brieger K; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Mukherjee B; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Pharoah PDP; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Wu AH; Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Pike MC; Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
  • Webb PM; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Pearce CL; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
J Natl Cancer Inst ; 113(3): 301-308, 2021 03 01.
Article em En | MEDLINE | ID: mdl-32766851
ABSTRACT

BACKGROUND:

Parity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studies from the Ovarian Cancer Association Consortium (OCAC). Histotype-specific associations, which have not been examined previously with large sample sizes, were also evaluated.

METHODS:

A pooled analysis of 10 470 invasive epithelial ovarian cancer cases and 16 942 controls was conducted. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between incomplete pregnancies and invasive epithelial ovarian cancer were estimated using logistic regression. All models were conditioned on OCAC study, race and ethnicity, age, and education level and adjusted for number of complete pregnancies, oral contraceptive use, and history of breastfeeding. The same approach was used for histotype-specific analyses.

RESULTS:

Ever having an incomplete pregnancy was associated with a 16% reduction in ovarian cancer risk (OR = 0.84, 95% CI = 0.79 to 0.89). There was a trend of decreasing risk with increasing number of incomplete pregnancies (2-sided Ptrend < .001). An inverse association was observed for all major histotypes; it was strongest for clear cell ovarian cancer.

CONCLUSIONS:

Incomplete pregnancies are associated with a reduced risk of invasive epithelial ovarian cancer. Pregnancy, including incomplete pregnancy, was associated with a greater reduction in risk of clear cell ovarian cancer, but the result was broadly consistent across histotypes. Future work should focus on understanding the mechanisms underlying this reduced risk.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Aborto Espontâneo / Aborto Induzido / Carcinoma Epitelial do Ovário Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Aborto Espontâneo / Aborto Induzido / Carcinoma Epitelial do Ovário Idioma: En Ano de publicação: 2021 Tipo de documento: Article