Highly Potent and Selective <i>N</i>-Aryl Oxamic Acid-Based Inhibitors for <i>Mycobacterium tuberculosis</i> Protein Tyrosine Phosphatase B.

Ruddraraju, Kasi Viswanatharaju; Aggarwal, Devesh; Niu, Congwei; Baker, Erica Anne; Zhang, Ruo-Yu; Wu, Li; Zhang, Zhong-Yin

Highly Potent and Selective N-Aryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B.

Ruddraraju, Kasi Viswanatharaju; Aggarwal, Devesh; Niu, Congwei; Baker, Erica Anne; Zhang, Ruo-Yu; Wu, Li; Zhang, Zhong-Yin.

Afiliação

Ruddraraju KV; Department of Medicinal Chemistry and Molecular Pharmacology, Department of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 4790, United States.
Aggarwal D; Department of Medicinal Chemistry and Molecular Pharmacology, Department of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 4790, United States.
Niu C; Department of Medicinal Chemistry and Molecular Pharmacology, Department of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 4790, United States.
Baker EA; Department of Medicinal Chemistry and Molecular Pharmacology, Department of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 4790, United States.
Zhang RY; Department of Medicinal Chemistry and Molecular Pharmacology, Department of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 4790, United States.
Wu L; Department of Medicinal Chemistry and Molecular Pharmacology, Department of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 4790, United States.
Zhang ZY; Department of Medicinal Chemistry and Molecular Pharmacology, Department of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 4790, United States.

J Med Chem ; 63(17): 9212-9227, 2020 09 10.

Article em En | MEDLINE | ID: mdl-32787087

Assuntos

Antituberculosos/química; Proteínas de Bactérias/antagonistas & inibidores; Mycobacterium tuberculosis/enzimologia; Ácido Oxâmico/química; Proteínas Tirosina Fosfatases/antagonistas & inibidores; Animais; Antituberculosos/metabolismo; Antituberculosos/farmacologia; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Sítios de Ligação; Domínio Catalítico; Permeabilidade da Membrana Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Desenho de Fármacos; Inibidores Enzimáticos/química; Inibidores Enzimáticos/metabolismo; Inibidores Enzimáticos/farmacologia; Cinética; Camundongos; Microssomos Hepáticos/metabolismo; Simulação de Acoplamento Molecular; Mutagênese Sítio-Dirigida; Mycobacterium tuberculosis/efeitos dos fármacos; Ácido Oxâmico/metabolismo; Ácido Oxâmico/farmacologia; Proteínas Tirosina Fosfatases/genética; Proteínas Tirosina Fosfatases/metabolismo; Células RAW 264.7; Relação Estrutura-Atividade

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Oxâmico / Proteínas de Bactérias / Proteínas Tirosina Fosfatases / Mycobacterium tuberculosis / Antituberculosos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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