Serum Protein Profiling Reveals a Landscape of Inflammation and Immune Signaling in Early-stage COVID-19 Infection.
Mol Cell Proteomics
; 19(11): 1749-1759, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32788344
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a highly contagious infection and threating the human lives in the world. The elevation of cytokines in blood is crucial to induce cytokine storm and immunosuppression in the transition of severity in COVID-19 patients. However, the comprehensive changes of serum proteins in COVID-19 patients throughout the SARS-CoV-2 infection is unknown. In this work, we developed a high-density antibody microarray and performed an in-depth proteomics analysis of serum samples collected from early COVID-19 (n = 15) and influenza (n = 13) patients. We identified a large set of differentially expressed proteins (n = 132) that participate in a landscape of inflammation and immune signaling related to the SARS-CoV-2 infection. Furthermore, the significant correlations of neutrophil and lymphocyte with the CCL2 and CXCL10 mediated cytokine signaling pathways was identified. These information are valuable for the understanding of COVID-19 pathogenesis, identification of biomarkers and development of the optimal anti-inflammation therapy.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
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Proteínas Sanguíneas
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Infecções por Coronavirus
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Tosse
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Influenza Humana
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Febre
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Mialgia
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Síndrome da Liberação de Citocina
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Cefaleia
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article