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Plaque Regression and Endothelial Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER).
Banerjee, Subhash; Luo, Ping; Reda, Domenic J; Latif, Faisal; Hastings, Jeffrey L; Armstrong, Ehrin J; Bagai, Jayant; Abu-Fadel, Mazen; Baskar, Amutharani; Kamath, Preeti; Lippe, Daniel; Wei, Yongliang; Scrymgeour, Alexandra; Gleason, Theresa C; Brilakis, Emmanouil S.
Afiliação
  • Banerjee S; Veterans Affairs North Texas Health Care System, Dallas (S.B., J.L.H.).
  • Luo P; University of Texas Southwestern Medical Center, Dallas (S.B., J.L.H., A.B., P.K.).
  • Reda DJ; Cooperative Studies Program Coordinating Center, Edward Hines, Jr Veterans Affairs Hospital, Hines, IL (P.L., D.J.R., D.L., Y.W.).
  • Latif F; Cooperative Studies Program Coordinating Center, Edward Hines, Jr Veterans Affairs Hospital, Hines, IL (P.L., D.J.R., D.L., Y.W.).
  • Hastings JL; Oklahoma City Veterans Affairs Medical Center (F.L.).
  • Armstrong EJ; University of Oklahoma Health Sciences Center (F.L., M.A.-F.).
  • Bagai J; Veterans Affairs North Texas Health Care System, Dallas (S.B., J.L.H.).
  • Abu-Fadel M; University of Texas Southwestern Medical Center, Dallas (S.B., J.L.H., A.B., P.K.).
  • Baskar A; Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO (E.J.A.).
  • Kamath P; Veterans Affairs Tennessee Valley Health Care System, Nashville (J.B.).
  • Lippe D; University of Oklahoma Health Sciences Center (F.L., M.A.-F.).
  • Wei Y; University of Texas Southwestern Medical Center, Dallas (S.B., J.L.H., A.B., P.K.).
  • Scrymgeour A; University of Texas Southwestern Medical Center, Dallas (S.B., J.L.H., A.B., P.K.).
  • Gleason TC; Cooperative Studies Program Coordinating Center, Edward Hines, Jr Veterans Affairs Hospital, Hines, IL (P.L., D.J.R., D.L., Y.W.).
  • Brilakis ES; Cooperative Studies Program Coordinating Center, Edward Hines, Jr Veterans Affairs Hospital, Hines, IL (P.L., D.J.R., D.L., Y.W.).
Circ Cardiovasc Interv ; 13(8): e008933, 2020 08.
Article em En | MEDLINE | ID: mdl-32791950
ABSTRACT

BACKGROUND:

Low-density lipoproteins (LDLs) are removed by extracorporeal filtration during LDL apheresis. It is mainly used in familial hyperlipidemia. The PREMIER trial (Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen) evaluated LDL apheresis in nonfamilial hyperlipidemia acute coronary syndrome patients treated with percutaneous coronary intervention.

METHODS:

We randomized 160 acute coronary syndrome patients at 4 Veterans Affairs centers within 72 hours of percutaneous coronary intervention to intensive lipid-lowering therapy (ILLT) comprising single LDL apheresis and statins versus standard medical therapy (SMT) with no LDL apheresis and statin therapy alone. Trial objectives constituted primary safety and primary efficacy end points and endothelial progenitor cell colony-forming unit mobilization in peripheral blood.

RESULTS:

Mean LDL reduction at discharge was 53% in ILLT and 17% in SMT groups (P<0.0001) from baseline levels of 116.3±34.3 and 110.7±32 mg/dL (P=0.2979), respectively. The incidence of the primary safety end point of major peri-percutaneous coronary intervention adverse events was similar in both groups (ILLT, 3; SMT, 0). The primary efficacy end point, percentage change in total plaque volume at 90 days by intravascular ultrasound, on average decreased by 4.81% in the ILLT group and increased by 2.31% in the SMT group (difference of means, -7.13 [95% CI, -14.59 to 0.34]; P=0.0611). The raw change in total plaque volume on average decreased more in the ILLT group than in the SMT group (-6.01 versus -0.95 mm3; difference of means, -5.06 [95% CI, -11.61 to 1.48]; P=0.1286). Similar results were obtained after adjusting for participating sites, age, preexisting coronary artery disease, diabetes mellitus, baseline LDL levels, and baseline plaque burden. There was robust endothelial progenitor cell colony-forming unit mobilization from baseline to 90 days in the ILLT group (P=0.0015) but not in SMT (P=0.0844).

CONCLUSIONS:

PREMIER is the first randomized clinical trial to demonstrate safety and a trend for early coronary plaque regression with LDL apheresis in nonfamilial hyperlipidemia acute coronary syndrome patients treated with percutaneous coronary intervention. Registration URL https//www.clinicaltrials.gov. Unique identifier NCT01004406 and NCT02347098.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Remoção de Componentes Sanguíneos / Doença da Artéria Coronariana / Inibidores de Hidroximetilglutaril-CoA Redutases / Síndrome Coronariana Aguda / Placa Aterosclerótica / Intervenção Coronária Percutânea / Células Progenitoras Endoteliais / Hiperlipidemias / Lipoproteínas LDL Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Remoção de Componentes Sanguíneos / Doença da Artéria Coronariana / Inibidores de Hidroximetilglutaril-CoA Redutases / Síndrome Coronariana Aguda / Placa Aterosclerótica / Intervenção Coronária Percutânea / Células Progenitoras Endoteliais / Hiperlipidemias / Lipoproteínas LDL Idioma: En Ano de publicação: 2020 Tipo de documento: Article