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Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors.
Hu, Zilun; Wang, Cailan; Sitkoff, Doree; Cheadle, Nathan L; Xu, Songmei; Muckelbauer, Jodi K; Adam, Leonard P; Wexler, Ruth R; Quan, Mimi L.
Afiliação
  • Hu Z; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA. Electronic address: zilun.hu@bms.com.
  • Wang C; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.
  • Sitkoff D; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.
  • Cheadle NL; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.
  • Xu S; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.
  • Muckelbauer JK; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.
  • Adam LP; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.
  • Wexler RR; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.
  • Quan ML; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.
Bioorg Med Chem Lett ; 30(21): 127474, 2020 11 01.
Article em En | MEDLINE | ID: mdl-32805407
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Inibidores de Proteínas Quinases / Quinases Associadas a rho Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Inibidores de Proteínas Quinases / Quinases Associadas a rho Idioma: En Ano de publicação: 2020 Tipo de documento: Article