3-Bromopyruvate-Conjugated Nanoplatform-Induced Pro-Death Autophagy for Enhanced Photodynamic Therapy against Hypoxic Tumor.

Deng, Yongyan; Song, Pengyu; Chen, Xiaohui; Huang, Yue; Hong, Liangjie; Jin, Qiao; Ji, Jian

Deng, Yongyan; Song, Pengyu; Chen, Xiaohui; Huang, Yue; Hong, Liangjie; Jin, Qiao; Ji, Jian.

Afiliação

Deng Y; MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, People's Republic of China.
Song P; MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, People's Republic of China.
Chen X; MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, People's Republic of China.
Huang Y; MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, People's Republic of China.
Hong L; MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, People's Republic of China.
Jin Q; MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, People's Republic of China.
Ji J; MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, People's Republic of China.

ACS Nano ; 14(8): 9711-9727, 2020 08 25.

Article em En | MEDLINE | ID: mdl-32806075

Assuntos

Neoplasias; Fotoquimioterapia; Porfirinas; Autofagia; Linhagem Celular Tumoral; Humanos; Hipóxia/tratamento farmacológico; Neoplasias/tratamento farmacológico; Fármacos Fotossensibilizantes/farmacologia; Fármacos Fotossensibilizantes/uso terapêutico; Porfirinas/farmacologia; Porfirinas/uso terapêutico; Piruvatos

Palavras-chave

3-bromopyruvate; hypoxia relief; photodynamic therapy; pro-death autophagy; respiration inhibition

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Porfirinas / Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Porfirinas / Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article