Dehydroxylative Fluorination of Tertiary Alcohols.
Org Lett
; 22(16): 6642-6646, 2020 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-32806144
A large number of fluorination methods have been developed, but the construction of a tertiary C-F bond remains challenging. Herein, we describe an efficient dehydroxylative fluorination of tertiary alcohols with Selectfluor via the activation of a hydroxyl group by a Ph2PCH2CH2PPh2/ICH2CH2I system. Although the reagents appear to be not compatible (Selectfluor with the phosphine and I- generated in situ), the reactions occur rapidly to give the desired products in moderate to high yields. This work may present a new discovery in fluorination of alcohols since the reported methods are mainly limited to primary and secondary alcohols.
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MEDLINE
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En
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2020
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Article