Decarbonylative Suzuki-Miyaura Cross-Coupling of Aroyl Chlorides.
Org Lett
; 22(16): 6434-6440, 2020 08 21.
Article
em En
| MEDLINE
| ID: mdl-32806154
ABSTRACT
Herein, we report a catalyst system for Pd-catalyzed decarbonylative Suzuki-Miyaura cross-coupling of aroyl chlorides with boronic acids to furnish biaryls. This strategy is suitable for a broad range of common aroyl chlorides and boronic acids. The synthetic utility is highlighted in the direct late-stage functionalization of pharmaceuticals and natural products capitalizing on the presence of carboxylic acid moiety. Extensive mechanistic and DFT studies provide key insight into the reaction mechanism and high decarbonylative cross-coupling selectivity.
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1
Base de dados:
MEDLINE
Assunto principal:
Paládio
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Ácidos Borônicos
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Cloretos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article