The effect of background strain on the behavioral phenotypes of the MDGA2+/- mouse model of autism spectrum disorder.
Genes Brain Behav
; 20(3): e12696, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-32808443
ABSTRACT
The membrane-associated mucin (MAM) domain containing glycosylphosphatidylinositol anchor 2 protein single knock-out mice (MDGA2+/- ) are models of ASD. We examined the behavioral phenotypes of male and female MDGA2+/- and wildtype mice on C57BL6/NJ and C57BL6/N backgrounds at 2 months of age and measured MDGA2, neuroligin 1 and neuroligin 2 levels at 7 months. Mice on the C57BL6/NJ background performed better than those on the C57BL6/N background in visual ability and in learning and memory performance in the Morris water maze and differed in measures of motor behavior and anxiety. Mice with the MDGA2+/- genotype differed from WT mice in motor, social and repetitive behavior and anxiety, but most of these effects involved interactions between MDGA2+/- genotype and background strain. The background strain also influenced MDGA2 levels and NLGN2 association in MDGA2+/- mice. Our findings emphasize the importance of the background strain used in studies of genetically modified mice.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenótipo
/
Moléculas de Adesão de Célula Nervosa
/
Proteínas Ligadas por GPI
/
Transtorno do Espectro Autista
/
Patrimônio Genético
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article