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An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice.
Khoryati, Liliane; Pham, Minh Nguyet; Sherve, McKenna; Kumari, Swarnima; Cook, Kevin; Pearson, Josh; Bogdani, Marika; Campbell, Daniel J; Gavin, Marc A.
Afiliação
  • Khoryati L; Immunology Research Program, Benaroya Research Institute, Seattle, WA 98101, USA.
  • Pham MN; Immunology Research Program, Benaroya Research Institute, Seattle, WA 98101, USA.
  • Sherve M; Immunology Research Program, Benaroya Research Institute, Seattle, WA 98101, USA.
  • Kumari S; Immunology Research Program, Benaroya Research Institute, Seattle, WA 98101, USA.
  • Cook K; Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, CA 94080, USA.
  • Pearson J; Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, CA 94080, USA.
  • Bogdani M; Matrix Biology Program, Benaroya Research Institute, Seattle, WA 98101, USA.
  • Campbell DJ; Immunology Research Program, Benaroya Research Institute, Seattle, WA 98101, USA. campbell@benaroyaresearch.org mgavin@omeros.com.
  • Gavin MA; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Sci Immunol ; 5(50)2020 08 14.
Article em En | MEDLINE | ID: mdl-32817295
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Fc / Autoimunidade / Interleucina-2 / Linfócitos T Reguladores / Proteínas Mutantes Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Fc / Autoimunidade / Interleucina-2 / Linfócitos T Reguladores / Proteínas Mutantes Idioma: En Ano de publicação: 2020 Tipo de documento: Article