OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.

Li, Fangzhou; Sun, Qianqian; Liu, Kun; Zhang, Ling; Lin, Ning; You, Kaiqiang; Liu, Mingwei; Kon, Ning; Tian, Feng; Mao, Zebin; Li, Tingting; Tong, Tanjun; Qin, Jun; Gu, Wei; Li, Dawei; Zhao, Wenhui

Li, Fangzhou; Sun, Qianqian; Liu, Kun; Zhang, Ling; Lin, Ning; You, Kaiqiang; Liu, Mingwei; Kon, Ning; Tian, Feng; Mao, Zebin; Li, Tingting; Tong, Tanjun; Qin, Jun; Gu, Wei; Li, Dawei; Zhao, Wenhui.

Afiliação

Li F; Department of Biochemistry and Biophysics, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Sun Q; Department of Biochemistry and Biophysics, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Liu K; Department of Biochemistry and Biophysics, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Zhang L; Center for Translational Medicine, The Affiliated Zhangjiagang Hospital of Soochow University, 68 Jiyang West Road, 215600, Suzhou, China.
Lin N; Department of Biochemistry and Biophysics, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
You K; Department of Biomedical informatics, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Post-translational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Liu M; State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing, China.
Kon N; Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY, 10032, USA.
Tian F; Department of Laboratory Animal Science, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Mao Z; Department of Biochemistry and Biophysics, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Li T; Department of Biomedical informatics, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Post-translational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Tong T; Department of Biochemistry and Biophysics, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.
Qin J; State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing, China.
Gu W; Institute for Cancer Genetics, and Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 1130 St. Nicholas Avenue, New York, NY, 10032, USA.
Li D; Center for Translational Medicine, The Affiliated Zhangjiagang Hospital of Soochow University, 68 Jiyang West Road, 215600, Suzhou, China. daweili@suda.edu.cn.
Zhao W; Department of Biochemistry and Biophysics, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China. zhao6025729@bjmu.edu.cn.

Nat Commun ; 11(1): 4184, 2020 08 21.

Article em En | MEDLINE | ID: mdl-32826889

Assuntos

Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo; Proteases Específicas de Ubiquitina/genética; Proteases Específicas de Ubiquitina/metabolismo; Animais; Linhagem Celular Tumoral; Proliferação de Células/genética; Modelos Animais de Doenças; Feminino; Regulação Neoplásica da Expressão Gênica; Técnicas de Silenciamento de Genes; Predisposição Genética para Doença/genética; Células HEK293; Xenoenxertos; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Masculino; Camundongos; Camundongos Knockout; Camundongos Nus; Pessoa de Meia-Idade; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/metabolismo; Neoplasias Ovarianas/patologia; Interferência de RNA; Transdução de Sinais; Transcriptoma; Ubiquitinação

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas de Ligação a DNA / Proteases Específicas de Ubiquitina Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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