[The role of mitochondria in pathological mechanisms of innate immunity in multiple]. / Rol' mitokhondrii v realizatsii patologicheskikh mekhanizmov vrozhdennogo immuniteta pri rasseyannom skleroze.

ABSTRACT

The review discusses the role of mitochondria in multiple sclerosis (MS). Previously, damage to the mitochondria was regarded as a manifestation of secondary damage to axons and neurons, i.e. as a marker of neurodenegation. Recently, the role of mitochondria in the early stages of MS development, when they could participate in the activation of innate immunity and trigger activation of autoimmune responses of acquired immunity, has been increasingly discussed. The role of polymorphism mitochondrial DNA changes in MS is discussed.